LYCOS RETRIEVER 
Diclofenac
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Diclofenac is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Diclofenac should not be taken late in pregnancy (the third trimester) because a similar drug is known to affect the baby's heart. Do not take diclofenac without first talking to your doctor if you are pregnant.
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Diclofenac has analgesic, antirheumatic, antipyretic and anti-inflammatory properties. It is a non-selective COX inhibitor. It works by blocking an enzyme in the body known as cyclo-oxygenase (COX). Cyclo-oxygenase is involved in the production of numerous chemicals in the body, including those known as prostaglandins. Prostaglandins are produced by the body in response to the presence of injury or disease and they make the nerves more sensitive to pain impulses. They produce pain, inflammation, and fever because they are hyperalgesic, pro-inflammatory, and pyretic.
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Diclofenac ophthalmic comes as a solution (liquid) to instill in the eyes. When diclofenac ophthalmic is used by patients recovering from cataract surgery, it is usually instilled 4 times a day beginning 24 hours after surgery and continuing for 2 weeks after surgery. When diclofenac ophthalmic is used by patients undergoing corneal refractive surgery, it is usually instilled one hour before the surgery, 15 minutes after the surgery, and then four times a day for up to 3 days. Use diclofenac eye drops at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use diclofenac eye drops exactly as directed.
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Diclofenac is used to relieve the pain, tenderness, inflammation (swelling), and stiffness caused by osteoarthritis and rheumatoid arthritis and ankylosing spondylitis. Immediate-release (short-acting) diclofenac (Cataflam) is ... used to treat painful menstrual periods and pain from other causes. Diclofenac is in a class of medications called nonsteroidal anti-inflammatory medications (NSAIDs). It works by stopping the body's production of a substance that causes pain and inflammation.
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Diclofenac is completely absorbed from the gastrointestinal tract after fasting oral administration, with peak plasma levels occurring in 1-4 hours. However, due to first-pass metabolism, only about 50% of the absorbed dose is systemically available. The mean terminal half-life in plasma is approximately 2 hours, but early elimination is much more rapid. Area under the plasma concentration curve (AUC) is dose-proportional within the range of 25 mg to 150 mg. Peak plasma levels are less than dose-proportional and are approximately 1.0, 1.5, and 2 mcg/ml for 25-mg, 50-mg, and 75-mg doses, respectively. It should be noted that the administration of several individual tablets may not yield equivalent results in peak concentration as the administration of one tablet of a higher strength. This is due to the uncertainty of complete gastric emptying of all tablets at once to the duodenum.
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Diclofenac